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Search Results for " dermal fibroblasts "

11

Compounds

Cat No. Product Name Synonyms Targets
T1850 Balicatib AAE581 Cysteine Protease
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
TN7117 Regaloside I Others
Regaloside I is the monomeric component in lily. Regaloside I could be the main constituent in protecting human dermal fibroblasts from UVA-induced morphological changes [1].
T5120 Rhamnose 6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose Calcium Channel , Endogenous Metabolite
Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind...
T3636 (E)-SIS3 SIS3,SIS3 HCl TGF-beta/Smad
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...
T80654 3,3′-Bisdemethylpinoresinol MMP
3,3′-Bisdemethylpinoresinol, a natural lignin derivative, exhibits MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts and can be isolated from the seeds of Morinda citrifolia [1].
T70826 PF-03671148
PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited ...
T78764 Anticancer agent 136 Apoptosis
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) and binds to Heat shock protein 90 (Hsp90) with a dissociation c...
T36929 Pal-KTTKS (acetate)
Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when use...
T35982 Capsorubin Apoptosis , Antiviral
Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMVN) at a concentration of 167 μM. capsorubin (1 μM) reduced ...
T36954 Nemorosone
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce...
T83744 Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferati...
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